Synthesis and Antimicrobial Activities of His(2-aryl)-Arg and Trp-His(2-aryl) Classes of Dipeptidomimetics.

نویسندگان

  • Amit Mahindra
  • Krishna K Sharma
  • Dinesh Rathore
  • Shabana I Khan
  • Melissa R Jacob
  • Rahul Jain
چکیده

In this communication, we report the design, synthesis and in vitro antimicrobial activity of ultra short peptidomimetics. Besides producing promising antibacterial activities against Staphylococcus aureus and methicillin-resistant S. aureus (MRSA), the dipeptidomimetics exhibited high antifungal activity against C. neoformans with IC50 values in the range of 0.16-19 μg/mL. The most potent analogs exhibited 4-fold higher activity than the currently used drug amphotericin B, with no apparent cytotoxicity in a panel of mammalian cell lines.

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عنوان ژورنال:
  • MedChemComm

دوره 5 5  شماره 

صفحات  -

تاریخ انتشار 2014